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Host genetics role in the pathogenesis of periodontal disease and caries
Author(s) -
Nibali Luigi,
Di Iorio Anna,
Tu YuKang,
Vieira Alexandre R.
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12639
Subject(s) - periodontitis , disease , medicine , genetic association , genome wide association study , medline , chronic periodontitis , cochrane library , candidate gene , meta analysis , bioinformatics , genetics , biology , gene , dentistry , genotype , single nucleotide polymorphism , biochemistry
Background This study aimed to produce the latest summary of the evidence for association of host genetic variants contributing to both periodontal diseases and caries. Materials and Methods Two systematic searches of the literature were conducted in Ovid Medline, Embase, LILACS and Cochrane Library for large candidate gene studies (CGS), systematic reviews and genome‐wide association studies reporting data on host genetic variants and presence of periodontal disease and caries. Results A total of 124 studies were included in the review (59 for the periodontitis outcome and 65 for the caries outcome), from an initial search of 15,487 titles. Gene variants associated with periodontitis were categorized based on strength of evidence and then compared with gene variants associated with caries. Several gene variants showed moderate to strong evidence of association with periodontitis, although none of them had also been associated with the caries trait. Conclusions Despite some potential aetiopathogenic similarities between periodontitis and caries, no genetic variants to date have clearly been associated with both diseases. Further studies or comparisons across studies with large sample size and clear phenotype definition could shed light into possible shared genetic risk factors for caries and periodontitis.