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Regular consumption of Lactobacillus reuteri‐containing lozenges reduces pregnancy gingivitis: an RCT
Author(s) -
Schlagenhauf Ulrich,
Jakob Lena,
Eigenthaler Martin,
Segerer Sabine,
JockelSchneider Yvonne,
Rehn Monika
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12606
Subject(s) - lactobacillus reuteri , medicine , gingivitis , placebo , pregnancy , randomized controlled trial , gastroenterology , gestation , lactobacillus , dentistry , biology , genetics , alternative medicine , pathology , bacteria
Abstract Aim This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women. Materials and Methods Forty‐five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index ( GI ) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for TNF ‐ α analysis. Subsequently participants were randomly provided with lozenges to be consumed 2 × daily until birth (approx. 7 weeks) containing ≥10 8 CFU L. reuteri ATCC PTA 5289 and ≥10 8 CFU L. reuteri DSM 17938 (test) or being devoid of L. reuteri (placebo). Within 2 days after birth recording of GI , PlI and blood sampling were repeated. Results At baseline, mean GI and mean PlI did not differ significantly between both groups. In the test group mean TNF ‐ α serum level was significantly ( p < 0.02) lower than in the placebo group. At reevaluation, mean GI and mean PlI of the test group were both significantly ( p < 0.0001) lower than in the placebo group. Mean TNF ‐ α serum level did no longer differ significantly between the groups. Conclusions The consumption of L. reuteri lozenges may be a useful adjunct in the control of pregnancy gingivitis.