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Is furcation involvement affected by adjunctive systemic amoxicillin plus metronidazole? A clinical trials exploratory subanalysis
Author(s) -
Eickholz Peter,
Nickles Katrin,
Koch Raphael,
Harks Inga,
Hoffmann Thomas,
Kim TiSun,
Kocher Thomas,
Meyle Jörg,
Kaner Doğan,
Schlagenhauf Ulrich,
Doering Stephan,
Gravemeier Martina,
Ehmke Benjamin
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12594
Subject(s) - metronidazole , placebo , medicine , amoxicillin , antibiotics , furcation defect , dentistry , periodontitis , randomized controlled trial , debridement (dental) , surgery , pathology , microbiology and biotechnology , alternative medicine , molar , biology
Objectives Evaluation of the clinical effect of systemic amoxicillin and metronidazole adjunctively to mechanical debridement at furcation sites. Material and Methods This is an exploratory per‐protocol collective subanalysis from a prospective, randomized, double‐blind, multi‐centre trial (ClinicalTrials.gov NCT 00707369) on the effect of adjunctive systemic amoxicillin 500 mg plus metronidazole 400 mg (3×/day, 7 days) use on furcation involvement in moderate to severe periodontitis. Outcome was the change in frequency of classes of furcation involvement after 27.5 months. Therapy comprised mechanical debridement in conjunction with antibiotic or placebo administration, and maintenance therapy at three months intervals. Results Three hundred and forty‐five patients (175 placebo, 170 antibiotics) with 6576 furcation sites (class 0 2956; class I 2370; class II 886; class III 364) were examined (3472 placebo, 3104 antibiotics). Pocket reduction/attachment gain at the furcation sites was noticeably better after antibiotics (1.2/0.6 mm) than after placebo (0.7/0.2 mm) 27.5 months after therapy. However, most furcation degrees were unchanged (placebo 61.5%/antibiotics 62.2%), more sites improved than deteriorated (20.3%/18.2%, 22.1%/15.7% respectively) and no differences in the change of furcation degrees between treatments could be detected. Conclusion Compared to placebo, prescription of adjunctive systemic antibiotics failed to show clinically relevant benefit with regard to furcation class involvement.