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Bidirectional relationship between renal function and periodontal disease in older Japanese women
Author(s) -
Yoshihara Akihiro,
Iwasaki Masanori,
Miyazaki Hideo,
Nakamura Kazutoshi
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12576
Subject(s) - periodontal disease , medicine , disease , renal function , dentistry
Abstract Objectives The purpose of this study was to evaluate the reciprocal effects of chronic kidney disease ( CKD ) and periodontal disease. Material and Methods A total of 332 postmenopausal never smoking women were enrolled, and their serum high‐sensitivity C‐reactive protein, serum osteocalcin and serum cystatin C levels were measured. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers, including clinical attachment level and the periodontal inflamed surface area ( PISA ), were also evaluated. Logistic regression analysis was conducted to evaluate the relationships between renal function and periodontal disease markers, serum osteocalcin level and hs CRP level. The prevalence‐rate ratios ( PRR s) on multiple Poisson regression analyses were determined to evaluate the relationships between periodontal disease markers and serum osteocalcin, serum cystatin C and serum hs CRP levels. Results On logistic regression analysis, PISA was significantly associated with serum cystatin C level. The odds ratio for serum cystatin C level was 2.44 ( p = 0.011). The PRR between serum cystatin C level and periodontal disease markers such as number of sites with clinical attachment level ≥6 mm was significantly positive (3.12, p < 0.001). Similar tendencies were shown for serum osteocalcin level. Conclusion This study suggests that CKD and periodontal disease can have reciprocal effects.