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Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis
Author(s) -
Akcalı Aliye,
Güven Yılmaz Suzan,
Lappin David F.,
Eğrilmez Sait,
Buduneli Nurcan
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12555
Subject(s) - medicine , gingivitis , saliva , cytokine , gastroenterology , inflammation , immunology , dental plaque , dentistry
Objectives This study aimed to investigate the levels of 11 oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis ( IU ) and systemically healthy individuals (H) with or without gingival inflammation. Material & Methods Twenty‐one patients with IU ( n = 21), and 22 systemically healthy individuals ( n = 22) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by ELISA . Bacterial gene copy numbers were determined by qPCR on plaque microbial DNA preparations. Results According to two‐step cluster analysis, anova and t ‐test: GCF , serum and salivary TNF ‐ α , IL ‐17A, IL ‐17A/E; GCF and serum IL ‐6; salivary IL ‐17F, and salivary and serum IL ‐17A/F levels were higher in the IU group than the H group ( p < 0.05). However, serum IL ‐10 and IL ‐17E levels were higher in the H group than the IU group ( p < 0.05). A. actinomycetemcomitans, F. nucleatum, S. oralis, A. naeslundii , and V. dispar counts were higher in IU group compared to H group ( p < 0.05). Conclusion Altered local and systemic cytokine profiles are associated with differences in the microbial plaque composition in IU . Anti‐inflammatory cytokines; IL ‐10, IL ‐17E are reduced in patients with IU and Th‐1 and Th‐17 driven inflammatory responses in biofluids are altered.