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Twenty years of enamel matrix derivative: the past, the present and the future
Author(s) -
Miron Richard J.,
Sculean Anton,
Cochran David L.,
Froum Stuart,
Zucchelli Giovanni,
Nemcovsky Carlos,
Donos Nikos,
Lyngstadaas Staale Petter,
Deschner James,
Dard Michel,
Stavropoulos Andreas,
Zhang Yufeng,
Trombelli Leonardo,
Kasaj Adrian,
Shirakata Yoshinori,
Cortellini Pierpaolo,
Tonetti Maurizio,
Rasperini Giulio,
Jepsen Søren,
Bosshardt Dieter D.
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12546
Subject(s) - enamel matrix derivative , cementum , periodontium , regeneration (biology) , periodontal fiber , dental alveolus , amelogenin , dentistry , enamel paint , medicine , matrix (chemical analysis) , biology , chemistry , microbiology and biotechnology , dentin , chromatography
Bacground On June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20 years of documented evidence supporting the clinical use of enamel matrix derivative ( EMD ). Original experiments led by Lars Hammarström demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarström has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium. Aims This review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials.