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Association between depression and periodontitis: a systematic review and meta‐analysis
Author(s) -
Araújo Milena Moreira,
Martins Carolina Castro,
Costa Lidiane Cristina Machado,
Cota Luís Otávio Miranda,
Faria Rodrigo Lamounier Araújo Melo,
Cunha Fabiano Araújo,
Costa Fernando Oliveira
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12510
Subject(s) - meta analysis , periodontitis , medicine , depression (economics) , odds ratio , publication bias , systematic review , cohort study , association (psychology) , medline , dentistry , psychology , biology , biochemistry , economics , psychotherapist , macroeconomics
Aim The aim of this systematic review and meta‐analysis was to assess the scientific evidence on the association between depression and periodontitis. Methods An electronic search was conducted in three databases until October 2015 ( PROSPERO ‐ CRD 42014006451). Hand searches and grey literature were also included. Search retrieved 423 potentially studies. Two independent reviewers selected the studies, extracted data and assessed risk bias through a modified version of Newcastle–Ottawa scale. Meta‐analysis was performed for the presence/absence of periodontitis (dichotomic). Summary effect measures and odds ratio ( OR ) 95% CI were calculated. Results After selecting the studies, 15 were included in the systematic review (eight cross‐sectional, six case–control and one cohort study). Six studies reported that depression was associated with periodontitis, whereas nine studies did not. The majority of studies had low risk of bias by methodological quality assessment. Meta‐analysis of seven cross‐sectional studies showed no significant association between depression and periodontitis ( OR = 1.03, 95% CI = 0.75–1.41). Conclusion Findings from the present systematic review showed a great heterogeneity among the studies and the summary effect measure of the meta‐analysis cannot affirm an association between depression and periodontitis. Future studies with different designs in distinct populations should be conducted to investigate this association.