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Use of molecular indicators of inflammation to assess the biocompatibility of all‐ceramic restorations
Author(s) -
Ariaans Kirsten,
Heussen Nicole,
Schiffer Hanna,
Wienert AnnaLena,
Plümäkers Birgit,
Rink Lothar,
Wolfart Stefan
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12500
Subject(s) - lithium disilicate , dentistry , medicine , bleeding on probing , inflammation , gingival inflammation , periodontitis , ceramic , materials science , periodontal disease , composite material
Aim The purpose of this in vivo study was quantification of inflammatory reaction to ceramic restorations made from lithium disilicate and zirconia by measurement of the concentration of indicators of inflammation in the gingival crevicular fluid ( GCF ). Material and Methods Patients out of three prospective cohort‐studies investigating three different all‐ceramic restoration materials for crowns and fixed dental prostheses were included. Patients needed an associated, unrestored tooth to serve as control. GCF samples were taken from the sulcus of the restored teeth and the related controls ( n = 59 pairs) and the concentrations of IL 1‐beta, IL ‐1ra and aMMP ‐8, as indicators of inflammation, were determined by use of ELISA tests. Periodontal status was also assessed clinically by measurement of pocket depth ( PD ), plaque index ( PI ) and bleeding on probing ( BOP ). Results The concentrations of the inflammation indicators were not significantly different between restored teeth and controls or between lithium disilicate and zirconia restorations ( p > 0.05). Furthermore, no significant difference between PD of restored teeth and controls or between groups could be shown. Conclusion Within the limitation of the study, treatment with all‐ceramic restorations did not induce inflammatory reactions in a group of periodontal healthy patients. No differences between the gingiva reactions of lithium disilicate and zirconia restorations could be shown.