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Prospective association of sex steroid concentrations with periodontal progression and incident tooth loss
Author(s) -
Samietz Stefanie,
Holtfreter Birte,
Friedrich Nele,
Mundt Torsten,
Hoffmann Wolfgang,
Völzke Henry,
Nauck Matthias,
Kocher Thomas,
Biffar Reiner
Publication year - 2016
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12493
Subject(s) - medicine , tooth loss , prospective cohort study , longitudinal study , waist , clinical attachment loss , testosterone (patch) , cohort study , cross sectional study , cohort , population , diabetes mellitus , bleeding on probing , physiology , demography , dentistry , periodontitis , endocrinology , body mass index , oral health , pathology , environmental health , sociology
Aim The aim of this study was to determine the prospective association between sex steroid concentrations with periodontal progression and incident tooth loss in men and women. Methods We used data from 1465 women and 1838 men (age 20–81 years) with completed five‐year‐follow‐up from the Study‐of‐Health‐in‐Pomerania, a population‐based longitudinal cohort. Serum levels of total testosterone ( TT ) and other sex steroids were measured. Mean clinical attachment loss ( CAL ) and the number of teeth were assessed. Generalized regression models were implemented for cross‐sectional and longitudinal analyses, adjusting for age, education, smoking, waist circumference, diabetes, physical activity, blood sampling time and time between baseline and follow‐up. Results Fully adjusted models revealed no consistent associations between TT and mean CAL , neither in cross‐sectional [men: ß = −0.0004 (−0.023;0.022), p = 0.97; women: ß = −0.033 (−0.057; −0.009), p = 0.006] nor in longitudinal analyses [men: ß = −0.033 (−0.100;0.034), p = 0.33; women: ß = −0.023 (−0.086;0.040), p = 0.47]. For tooth loss, neither cross‐sectional nor longitudinal associations with any of the sex steroid concentrations were found. Conclusions No consistent associations of sexual steroids with periodontal progression or tooth loss were found. Further cohort studies are necessary to evaluate possible associations between endocrinological parameters, like supra‐ or subphysiologic testosterone concentrations, and periodontal progression or tooth loss.