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The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial
Author(s) -
Laleman Isabelle,
Yilmaz Eftal,
Ozcelik Onur,
Haytac Cenk,
Pauwels Martine,
Herrero Esteban R.,
Slomka Vera,
Quirynen Marc,
Alkaya Bahar,
Teughels Wim
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12464
Subject(s) - probiotic , scaling and root planing , medicine , placebo , periodontitis , randomized controlled trial , gingivitis , bleeding on probing , prevotella intermedia , clinical endpoint , dentistry , gastroenterology , chronic periodontitis , biology , bacteria , pathology , genetics , alternative medicine , porphyromonas gingivalis
Aim To evaluate the adjunctive effects of a Streptococcus oralis KJ 3, Streptococcus uberis KJ 2 and Streptococcus rattus JH 145 containing probiotic tablet after scaling and root planing ( SRP ). Materials and Methods Forty‐eight periodontitis patients were included in this double‐blind, placebo‐controlled clinical trial. After root planing, patients used either a placebo or a probiotic tablet twice a day for 12 weeks. The pocket probing depth (primary outcome measure), bleeding on probing and relative attachment levels were measured at baseline, 12 and 24 weeks. At baseline, 4, 8, 12 and 24 weeks, microbiological sampling was performed and plaque and gingival indices were recorded. Results The primary and secondary outcome measures were significantly ( p < 0.05) improved at the 12‐ and the 24‐week evaluation in both groups. However, no significant inter‐group differences could be detected at any time point, except from the % of sites with plaque that were significantly lower in the probiotic group than in the control group at the 24‐week evaluation. In addition, at the 12‐week time point, the salivary Prevotella intermedia counts were significantly lower in the probiotic group. Conclusions No differences were detected when comparing the adjunctive use of a placebo or the investigated streptococci containing probiotic tablet after SRP . ClinicalTrials.gov Identifier: NCT 02403960.