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The association between subgingival periodontal pathogens and systemic inflammation
Author(s) -
Winning Lewis,
Patterson Christopher C.,
Cullen Kathy M.,
Stevenson Kathryn A.,
Lundy Fionnuala T.,
Kee Frank,
Linden Gerard J.
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12450
Subject(s) - tannerella forsythia , treponema denticola , aggregatibacter actinomycetemcomitans , medicine , porphyromonas gingivalis , c reactive protein , periodontal examination , clinical attachment loss , confounding , confidence interval , periodontitis , periodontal pathogen , gastroenterology , dentistry , inflammation , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Aim To investigate associations between periodontal disease pathogens and levels of systemic inflammation measured by C‐reactive protein ( CRP ). Methods A representative sample of dentate 60–70‐year‐old men in Northern Ireland had a comprehensive periodontal examination. Men taking statins were excluded. Subgingival plaque samples were analysed by quantitative real time PCR to identify the presence of Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis , Treponema denticola and Tannerella forsythia . High‐sensitivity CRP (mg/l) was measured from fasting blood samples. Multiple linear regression analysis was performed using log‐transformed CRP concentration as the dependent variable, with the presence of each periodontal pathogen as predictor variables, with adjustment for various potential confounders. Results A total of 518 men (mean age 63.6 SD 3.0 years) were included in the analysis. Multiple regression analysis showed that body mass index ( p < 0.001), current smoking ( p < 0.01), the detectable presence of P. gingivalis ( p < 0.01) and hypertension ( p = 0.01), were independently associated with an increased CRP . The detectable presence of P. gingivalis was associated with a 20% (95% confidence interval 4–35%) increase in CRP (mg/l) after adjustment for all other predictor variables. Conclusion In these 60–70‐year‐old dentate men, the presence of P. gingivalis in subgingival plaque was significantly associated with a raised level of C‐reactive protein.