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Effect of application of a PVP ‐iodine solution before and during subgingival ultrasonic instrumentation on post‐treatment bacteraemia: a randomized single‐centre placebo‐controlled clinical trial
Author(s) -
Sahrmann Philipp,
Manz Andrea,
Attin Thomas,
Zbinden Reinhard,
Schmidlin Patrick R.
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12416
Subject(s) - medicine , periodontitis , iodine , concomitant , dentistry , bacteremia , randomized controlled trial , placebo , antibiotics , microbiology and biotechnology , chemistry , pathology , biology , alternative medicine , organic chemistry
Background To assess the effect of concomitant subgingival rinsing with 10% PVP ‐iodine during subgingival instrumentation on the prevalence and magnitude of bacteraemia of oral origin. Materials and Methods Subgingival instrumentation was performed with water or PVP ‐iodine rinse in patients with periodontitis. Prior to instrumentation, subjects gargled for 1 min with the allocated liquid. Pockets were then rinsed for 1 min and subgingivally instrumented with liquid‐cooled (water/ PVP ‐iodine) ultrasonic scalers (1 min). Two minutes later, a blood sample from the arm vein was drawn using a lysis centrifugation blood culture system for quantitative microbiological analysis. Non‐parametric statistical tests were performed to assess differences in the prevalence and extent of bacteraemia between groups. Results Of the 19 samples in each group, oral‐borne bacteraemia was detected in 10 of the control and 2 of the test samples. With an average of 3.0 [1; 5] colony forming units, significantly less bacteria and bacteraemia were found in the test group compared to the controls (12.2 [1; 46]) ( p = 0.003). Anaerobic bacteria were not found in the test group. Conclusions Bacteraemia after subgingival instrumentation with concomitant PVP ‐iodine rinsing is reduced but not eliminated. Therefore, it might be recommended for patients at a high risk of endocarditis or infection of endoprostheses. However, preventive antibiotic treatment should not be omitted.