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Ridge regeneration of damaged extraction sockets using rh BMP ‐2: an experimental study in canine
Author(s) -
Lee JungSeok,
Jung JaeSuk,
Im GunIl,
Kim ByungSoo,
Cho KyooSung,
Kim ChangSung
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12414
Subject(s) - buccal administration , barrier membrane , chemistry , dentistry , bone morphogenetic protein , extraction (chemistry) , grafting , beagle , regeneration (biology) , bone grafting , membrane , medicine , biology , microbiology and biotechnology , chromatography , biochemistry , organic chemistry , gene , polymer
Objectives This study evaluated the dimensional ridge alteration in a buccal‐bone‐deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rh BMP ‐2) or a collagen membrane covering. Material and Methods In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and grafting with (2) deproteinized bovine bone mineral ( DBBM ), (3) DBBM /rh BMP ‐2 and (4) DBBM covered with a collagen membrane ( DBBM /Membrane). Quantitative/qualitative analyses were performed radiographically/histologically after 8 weeks. Results Buccal‐deficient extraction sockets healed with significant reduction in buccolingual dimension along the entire length of the socket, but all grafting techniques reduced the dimensional changes compared to the non‐grafted control sites. Histologically, sites received DBBM only exhibited minimal regeneration, whereas sites grafted with DBBM /rh BMP ‐2 or DBBM /Membrane exhibited greater new bone formation extending the entire augmented area. Conclusions Buccal‐bone‐deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rh BMP ‐2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.