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The clinical response and systemic effects of non‐surgical periodontal therapy in end‐stage renal disease patients: a 6‐month randomized controlled clinical trial
Author(s) -
Fang Fuchun,
Wu Buling,
Qu Qian,
Gao Jie,
Yan Wenjuan,
Huang Xin,
Ma Dandan,
Yue Jin,
Chen Ting,
Liu Fei,
Liu Ying
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12411
Subject(s) - medicine , blood urea nitrogen , periodontitis , randomized controlled trial , clinical trial , creatinine , end stage renal disease , clinical attachment loss , gastroenterology , disease
Aims Scientific evidence on the effects of chronic periodontitis on end‐stage renal disease ( ESRD ) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non‐surgical periodontal therapy on the clinical response and systemic status of ESRD patients. Materials and Methods Patients in the intervention group ( n = 48) received non‐surgical periodontal therapy and then a supragingival prophylaxis at the 3‐month follow up, and those in the control group ( n = 49) received no intervention throughout the study. At 6 weeks, 3 months, and 6 months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles. Results The results showed a significant improvement in clinical periodontal parameters ( p < 0.05) in the intervention group. Compared to the control group, the intervention group had significantly lower high‐sensitivity C‐reactive protein at 3 months and 6 months. Significant improvements were found ( p < 0.05) in interleukin‐6, ferritin, albumin, creatinine, blood urea nitrogen, and transferrin after therapy. Conclusions Non‐surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in ESRD patients. Non‐surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in ESRD patients.