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Effect of non‐surgical periodontal therapy on plasma homocysteine levels in Indian population with chronic periodontitis: a pilot study
Author(s) -
Bhardwaj Smiti,
Prabhuji M. L. Venkatesh,
Karthikeyan Bangalore Vardhan
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12374
Subject(s) - medicine , chronic periodontitis , periodontitis , homocysteine , gastroenterology , dentistry , scaling and root planing , periodontal disease , clinical attachment loss
Aim Homocysteine (Hcy) is implicated in the development of cardiovascular diseases ( CVD ). The effect of periodontal disease and periodontal therapy on plasma Hcy remains controversial. Hence, in this pilot study we assessed the effect of periodontal disease and non‐surgical periodontal therapy ( NSPT ) on plasma Hcy in systemically healthy Indian subjects. Materials and methods Forty participants (30 to 39 years) were enrolled in the study and were divided into two groups based on gingival index, probing depth, and clinical attachment level ( CAL ): Healthy (control group; n = 20) and Chronic Periodontitis (test group; n = 20). Plasma samples were collected and quantified at baseline and 12 weeks after scaling and root planing ( SRP ) for Hcy using High Performance Liquid Chromatography with fluorescent detection ( HPLC ‐fld). Results Plasma Hcy levels of chronic periodontitis (17.87 ± 1.21 μ mol/l) subjects was significantly higher than healthy subjects (9.09 ± 2.11 μ mol/l). Post‐therapy, the plasma Hcy concentration reduced significantly (11.34 ± 1.87 μ mol/l) ( p < 0.05). Conclusion The rise and descent of plasma Hcy levels with periodontal inflammation and therapy, respectively, indicate a direct relationship of Hcy with chronic periodontitis. NSPT may be employed as an adjunctive Hcy Lowering Therapy, contributing towards primary prevention against CVD 's.