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Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats
Author(s) -
Fügl Alexander,
Gruber Reinhard,
Agis Hermann,
Lzicar Hannah,
Keibl Claudia,
Schwarze Uwe Yacine,
Dvorak Gabriella
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12342
Subject(s) - calcitriol , mandible (arthropod mouthpart) , dental alveolus , maxilla , regeneration (biology) , vitamin d and neurology , medicine , endocrinology , vitamin d deficiency , cholecalciferol , vitamin , dentistry , biology , botany , microbiology and biotechnology , genus
Aim Vitamin D deficiency is considered to diminish bone regeneration. Yet, raising the serum levels takes months. A topic application of the active vitamin D metabolite, calcitriol, may be an effective approach. Thus, it becomes important to know the effect of vitamin D deficiency and local application on alveolar bone regeneration. Material and Methods Sixty rats were divided into three groups; two vitamin depletion groups and a control group. Identical single defects (2 mm diameter) were created in the maxilla and mandible treated with calcitriol soaked collagen in one deficiency group while in the other two groups not. Histomorphometric analysis and micro CT s were performed after 1 and 3 weeks. Serum levels of 25( OH )D 3 and PTH were determined. Results Bone formation rate significantly increased within the observation period in all groups. Bone regeneration was higher in the maxilla than in the mandible. However, bone regeneration was lower in the control group compared to vitamin depletion groups, with no significant effects by local administration of calcitriol (micro CT mandible p = 0.003, maxilla p < 0.001; histomorphometry maxilla p = 0.035, mandible p = 0.18). Conclusion Vitamin D deficiency not necessarily impairs bone regeneration in the rat jaw and a single local calcitriol application does not enhance healing.