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Are anti‐inflammatory agents effective in treating gingivitis as solo or adjunct therapies? A systematic review
Author(s) -
Polak David,
Martin Conchita,
SanzSánchez Ignacio,
Beyth Nurit,
Shapira Lior
Publication year - 2015
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12340
Subject(s) - gingivitis , medicine , adjunct , gingival inflammation , dentistry , randomized controlled trial , adjunctive treatment , philosophy , linguistics
Objective Systematically review the scientific evidence for efficiency of anti‐inflammatory agents against gingivitis, either as solo treatments or adjunctive therapies. Methods A protocol was developed aimed to answer the following focused question: “Are anti‐inflammatory agents effective in treating gingivitis as solo or adjunct therapies?” RCT s and cohort studies on anti‐inflammatory agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub‐analysis was performed dividing the active agents into anti‐inflammatory and other drugs. Results The search identified 3188 studies, of which 14 RCT s met the inclusion criteria. The use of anti‐inflammatory or other agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCT s on inflammatory drugs could be meta‐analysed, showing a statistically significant reduction in the GI in the experimental group [ WMD = −0.090; 95% CI (−0.105; −0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively). Conclusions Most of the tested material showed beneficial effect as anti‐inflammatory agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.