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Periodontal status and serum biomarkers levels in haemodialysis patients
Author(s) -
Rodrigues Vandilson P.,
Libério Silvana A.,
Lopes Fernanda F.,
Thomaz Erika B. F. A.,
Guerra Rosane N. M.,
GomesFilho Isaac S.,
Pereira Antonio L. A.
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12283
Subject(s) - medicine , periodontitis , gastroenterology , albumin , transferrin , creatinine , clinical attachment loss , bleeding on probing , periodontal examination , alkaline phosphatase , population , serum iron , dentistry , anemia , chemistry , biochemistry , environmental health , enzyme
Abstract Aim To investigate the association between periodontal status and serum biomarkers levels in haemodialysis patients. Methods This cross‐sectional study included 96 haemodialysis patients. The periodontal evaluation was realized using clinical attachment level ( CAL ), probing depth ( PD ), gingival bleeding index ( GBI ), visible plaque index ( VPI ) and gingival index ( GI ). Biochemical and haematological data – serum albumin, phosphorus, creatinine, transferrin, ferritin, iron, alkaline phosphatase, calcium, potassium and haemoglobin – were collected from the medical records. The subject was diagnosed with periodontitis if he/she had at least two inter‐proximal sites in different teeth with CAL ≥4 mm and/or at least two inter‐proximal sites in separate teeth with PD ≥5 mm. Results The study population consisted of 45 men and 51 women, with mean time under haemodialysis of 45.6 ± 33.1 months. Periodontitis was observed in 59.4% of the subjects. The periodontitis group had albumin ( p = 0.021) and phosphorus ( p = 0.024) serum levels lower than the no periodontitis group. Thus, there was a positive association of periodontitis with hypoalbuminaemia ( OR = 9.10, p = 0.006) and a negative association with hyperphosphataemia ( OR = 0.21, p = 0.010). Conclusions These findings suggest that periodontitis is associated with albumin and phosphorus serum levels in haemodialysis patients.