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Is gingival bleeding a symptom of patients with type 1 von W illebrand disease? A case–control study
Author(s) -
Weickert Lisa,
Miesbach Wolfgang,
Alesci Sonja Rosa,
Eickholz Peter,
Nickles Katrin
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12274
Subject(s) - medicine , bleeding on probing , gingivitis , von willebrand disease , gingival inflammation , von willebrand factor , periodontal disease , dentistry , gastroenterology , mucosal inflammation , inflammation , platelet
Background Von W illebrand disease ( VWD ) is the most common inherent bleeding disorder resulting in prolonged bleeding time. Gingival bleeding is a frequently reported symptom of VWD . However, gingival bleeding is also known as a leading symptom of plaque‐induced gingivitis and untreated periodontal disease. Gingival bleeding in VWD patients ( VWD ) may be triggered by gingival inflammation and not a genuine symptom. Thus, this study evaluated whether type 1 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm. Methods Fifty cases and 40 controls were examined haematologically ( VWF antigen, VWF R istocetin cofactor, factor VIII activity) and periodontally [ G ingival B leeding I ndex ( GBI ), bleeding on probing ( BOP ), P laque C ontrol R ecord ( PCR ), periodontal inflamed surface area ( PISA ), vertical probing attachment level]. Results GBI was significantly higher in controls (12.2%) than in VWD (10%). The study failed to find a significant difference regarding BOP between VWD (17%) and controls (17.2%). Multiple regressions identified PCR and PISA to be associated with GBI and BOP . VWD was negatively associated with GBI . Smoking and number of remaining teeth was negatively associated with BOP . Conclusion VWD is not associated with a more pronounced inflammatory response to the oral biofilm in terms of GBI and BOP .