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Periodontal pathogens and associated factors in aggressive periodontitis: results 5–17 years after active periodontal therapy
Author(s) -
MeyerBäumer Amelie,
Eick Sigrun,
Mertens Christian,
Uhlmann Lorenz,
Hagenfeld Daniel,
Eickholz Peter,
Kim TiSun,
Cosgarea Raluca
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12255
Subject(s) - treponema denticola , tannerella forsythia , aggregatibacter actinomycetemcomitans , medicine , aggressive periodontitis , porphyromonas gingivalis , forsythia , chronic periodontitis , periodontitis , periodontal examination , periodontal pathogen , dentistry , gastroenterology , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Objectives To assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (AgP) after active periodontal therapy ( APT ) and further influencing factors. Material & Methods Microbiological samples were taken from 73 patients with AgP 5–17 years after APT at 292 sites (deepest site per quadrant). Real‐time polymerase chain reactions were used to detect the periodontal pathogens Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis , Tannerella forsythia and Treponema denticola . Uni‐ and multivariate analyses evaluated the associations between pathogens and recurrence of disease, smoking and adjunctive antibiotic therapy. Results At re‐examination A. actinomycetemcomitans could be detected in six patients (8.2%), P. gingivalis in 24 (32.9%), T. forsythia in 31 (42.5%) and T. denticola in 35 (48.0%). Increased levels of T. forsythia and T. denticola at re‐examination were significantly associated with recurrence of disease in multivariate analyses ( OR : 12.72, p < 0.001; OR 5.55, p = 0.002 respectively). Furthermore, high counts of T. denticola were found in patients with increased percentage of sites with clinical attachment levels ( CAL ) ≥6 mm compared to those with low counts (13.8% versus 3.2%, p = 0.005). Conclusion In patients with recurrence of disease T. forsythia and T. denticola were detected more frequently and in higher counts. Furthermore, T. denticola was found more frequently in patients with increased CAL .