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Experimental peri‐implant mucositis at different implant surfaces
Author(s) -
Schwarz Frank,
Mihatovic Ilja,
Golubovic Vladimir,
Eick Sigrun,
Iglhaut Theresa,
Becker Jürgen
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12240
Subject(s) - mucositis , implant , cd68 , dentistry , medicine , periodontitis , maxilla , materials science , pathology , immunohistochemistry , surgery , radiation therapy
Objectives To histologically and immunologically assess experimental peri‐implant mucositis at surface enhanced modified (mod) hydrophilic titanium implants. Materials and Methods In a split‐mouth design ( n = 6 foxhounds), four different implants were inserted on each side of the maxilla: three titanium‐zirconium alloy implants (TiZr) with either modSLA (sand‐blasted, acid etched and chemically mod), modMA (machined, acid etched and chemically mod), or M (machined) surfaces in the transmucosal portion, and one titanium implant with a machined transmucosal portion (TiM). Experimental mucositis was induced at one randomly assigned side (NPC), whereas the contra‐lateral maxillary side received mechanical plaque removal three times per week (PC). At 16 weeks, tissue biopsies were processed for histological (primary outcome: apical extension of the inflammatory cell infiltrate measured from the mucosal margin – PM‐ aICT ) and immunohistochemical (CD68 antigen reactivity) analyses. Peri‐implant sulcus fluid was analysed for interleukin (IL)‐1β, IL‐8, matrix metalloproteinase (MMP)‐8 and myeloperoxidase (MPO). Results Mean PM‐ aICT values varied between 1.86 (TiZrmodSLA) and 3.40 mm (TiM) in the UPC group, and between 0.88 (TiZrmodSLA) and 2.08 mm (TiZrM) in the PC group. Mean CD68, IL‐1β, IL‐8, MMP‐8 and MPO values were equally distributed between mod‐ and control implants in both NPC and PC groups. Conclusions The progression of experimental mucositis was comparable at all implant surfaces investigated.