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The interaction between beta‐3 adrenergic receptor polymorphism and obesity to periodontal disease in community‐dwelling elderly Japanese
Author(s) -
Yoshihara Akihiro,
Sugita Noriko,
Iwasaki Masanori,
Miyazaki Hideo,
Nakamura Kazutoshi
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12235
Subject(s) - body mass index , obesity , medicine , beta 3 adrenergic receptor , genotype , endocrinology , receptor , polymorphism (computer science) , poisson regression , adrenergic receptor , biology , genetics , population , gene , environmental health
Objectives The purpose of this study was to elucidate whether the association between beta‐3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. Material and Methods We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta‐3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level ( CAL ) were measured. After selecting subjects for each body mass index ( BMI ) level, the prevalence rate ratio ( PRR ) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta‐3 adrenergic receptor polymorphism. The number of sites with CAL ≥6 mm was used as a dependent variable, and beta‐3 adrenergic receptor genotype [categorized as Arg non‐carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites ( n ) to an offset variable. Results The PRR of the beta‐3 adrenergic receptor genotype for the number of sites of CAL ≥6 mm showed a positive association in subjects with BMI ≥25.0 and increased markedly with BMI . The PRR in subjects with BMI ≥30 was 3.10 ( p < 0.0001). Conclusion This study indicates a positive association between periodontal disease and the beta‐3 adrenergic receptor genotype in obese individuals.