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Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor‐ α in children
Author(s) -
Kâ Khady,
Rousseau MarieClaude,
Tran Simon D.,
Kaartinen Mari T.,
Myneni Vamsee D.,
Henderson Mélanie,
Nicolau Belinda
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12232
Subject(s) - medicine , osteocalcin , endocrinology , obesity , odds ratio , family history , tumor necrosis factor alpha , inflammation , alkaline phosphatase , biology , biochemistry , enzyme
Background Osteocalcin, a protein secreted by osteoblasts during bone formation, is negatively associated with adult periodontal disease. Little is known about this association in children. Aim To examine the extent to which plasma undercarboxylated osteocalcin (uc OC ) is associated with gingival crevicular fluid tumour necrosis factor‐alpha ( GCF TNF ‐ α ) – a potential marker of gingival inflammation – in children. Methods We used data from the Q uebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross‐sectional analysis from the baseline visit includes 120 children aged 8–10 years. Plasma uc OC and GCF TNF ‐ α levels were determined by enzyme‐linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with TNF ‐ α level as the dependent variable. Results A 1‐ng/ml increase in uc OC was associated with a 0.96% decrease (95% confidence interval ( CI ): −1.69, −0.23) in GCF TNF ‐ α level. Conclusion A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.