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Progression of attachment loss is strongly associated with presence of the JP 2 genotype of Aggregatibacter actinomycetemcomitans : a prospective cohort study of a young adolescent population
Author(s) -
Höglund Åberg Carola,
Kwamin Francis,
Claesson Rolf,
Dahlén Gunnar,
Johansson Anders,
Haubek Dorte
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12209
Subject(s) - aggregatibacter actinomycetemcomitans , genotype , medicine , clinical attachment loss , population , gastroenterology , periodontitis , biology , genetics , gene , environmental health , porphyromonas gingivalis
Aim To assess the progression of attachment loss ( AL ) during a 2‐year period according to the presence of JP 2 and non‐ JP 2 genotypes of Aggregatibacter actinomycetemcomitans in a Ghanaian adolescent population. Methods A total of 500 adolescents (mean age 13.2 years, SD ± 1.5) were enrolled in the study. After 2 years, 397 (79.4%) returned for a periodontal re‐examination, including the measurement of AL . The carrier status of the JP 2 and non‐ JP 2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination 2 years earlier. Results Individuals who carried the JP 2 genotype of A. actinomycetemcomitans had a significantly increased risk [relative risk ( RR ) = 7.3] of developing AL ≥ 3 mm. The mean AL at the follow‐up and the mean 2‐year progression of AL were significantly higher in the JP 2 genotype‐positive group ( n = 38) compared with the group positive for the non‐ JP 2 genotypes of A. actinomycetemcomitans ( n = 169), and the group of A. actinomycetemcomitans ‐negative individuals ( n = 190). The JP 2 genotype was strongly associated with the progression of AL ≥ 3 mm ( OR = 14.3). The non‐ JP 2 genotypes of A. actinomycetemcomitans were also, however, less pronounced, associated with the progression of AL ≥ 3 mm ( OR = 3.4). Conclusion The JP 2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL .