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Sinus augmentation using BMP ‐2 in a bovine hydroxyapatite/collagen carrier in dogs
Author(s) -
Cha JaeKook,
Lee JungSeok,
Kim MinSoo,
Choi SeongHo,
Cho KyooSung,
Jung UiWon
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12174
Subject(s) - sinus (botany) , bone morphogenetic protein , bone formation , bone morphogenetic protein 2 , chemistry , dentistry , andrology , medicine , pathology , anatomy , urology , endocrinology , biology , biochemistry , in vitro , botany , gene , genus
Aim The objective of this study was to determine the efficacy of bone morphogenetic protein 2 ( BMP ‐2) in a bovine hydroxyapatite/collagen ( BHC ) carrier to augment bone formation in a canine nasal sinus model. Methods Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli ‐derived BMP‐2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli ‐derived BMP‐2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro‐computed tomography and histometric analyses. Results Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP ‐2 groups compared with control. Conclusion BMP‐2 in a BHC carrier, even at the low 0.1‐mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.