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Inter‐bacterial correlations in subgingival biofilms: a large‐scale survey
Author(s) -
Loozen Gitte,
Ozcelik Onur,
Boon Nico,
De Mol Antony,
Schoen Christian,
Quirynen Marc,
Teughels Wim
Publication year - 2014
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12167
Subject(s) - treponema denticola , tannerella forsythia , porphyromonas gingivalis , periodontitis , biology , abundance (ecology) , fusobacterium nucleatum , periodontal disease , microbiology and biotechnology , medicine , dentistry , ecology , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Abstract Aim Although the complexity of the oral ecology and the ecological differences between health and disease are well accepted, a clear view on the dynamics in relation to disease is lacking. In this study, the prevalence and abundance of 20 key oral bacteria was assessed in health and disease and more importantly a closer look was given to the inter‐bacterial relationships. Materials and methods A blinded microbiological database was analysed in this cross‐sectional, retrospective study. The database was constructed based on microbiological analyses of samples from 6308 patients, with gradations of periodontitis (healthy to periodontitis). Data concerning the abundance of 20 oral bacteria and probing pocket depth were provided. Results Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola, Eubacterium nodatum, Porphyromonas micra and Porphyromonas intermedia showed a clear increase in abundance and prevalence with increasing pocket depth. Correlation matrices illustrated that almost all microorganisms were in one way correlated to other species and most of these correlations were significant. Several beneficial bacteria showed strong correlations with other beneficial bacteria. Conclusion Knowledge on bacterial correlations can pave the way for new treatment options focusing on restoring the shifted balance.