Premium
Matrix metalloproteinase‐1 promoter ‐1607 1G/2G polymorphism and chronic periodontitis susceptibility: a meta‐analysis and systematic review
Author(s) -
Li Wenyang,
Xiao Lin,
Hu Jing
Publication year - 2013
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12166
Subject(s) - meta analysis , polymorphism (computer science) , periodontitis , medicine , genetics , chronic periodontitis , biology , gastroenterology , allele , gene
Aim Matrix metalloproteinase‐1 promoter ‐1607 1G/2G (rs1799750) polymorphism have been shown to confer genetic susceptibility to chronic periodontitis ( CP ), but the results are inconsistent. Materials and Methods A meta‐analysis and systematic review was performed to accomplish a more precise estimation of the relationship. Results Pooled estimates revealed that there was no significant association between this polymorphism and CP risk in Caucasian and Asian populations. In addition, it was reported by three Brazilian studies that no significant association was found for this polymorphism with CP risk in a Brazilian mixed population. Besides, there was no significant association of this polymorphism with mild to moderate and severe CP risk in both Caucasian and Asian populations. Moreover, both non‐smokers and smokers did not have a significant association between this polymorphism and susceptibility to CP in Caucasian population. Conclusions Matrix metalloproteinase‐1 promoter −1607 1G/2G (rs1799750) polymorphism may have no effect on the disease susceptibility of CP in Caucasian, Asian and Brazilian mixed populations. Besides, this polymorphism may not play a direct role in severity of CP among both Caucasian and Asian populations, and between this polymorphism and smoking there may be no interactions to be associated with CP risk in Caucasian population.