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Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes
Author(s) -
Timonen Petra,
Saxlin Tuomas,
Knuuttila Matti,
Suominen Anna Liisa,
Jula Antti,
Tervonen Tellervo,
Ylöstalo Pekka
Publication year - 2013
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12162
Subject(s) - medicine , insulin resistance , diabetes mellitus , poisson regression , periodontal disease , incidence (geometry) , homeostasis , insulin , dentistry , endocrinology , population , environmental health , physics , optics
Aim The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non‐smoking adults without manifest diabetes. Material and Methods We analysed data from a Health 2000 Survey consisting of dentate subjects without any indication of diabetes, aged between 30 and 64, who had never smoked and who had participated in the Follow‐up Study on Finnish Adults' Oral Health about 4 years later ( n = 157). The Homeostasis Model Assessment Indices were used to measure insulin resistance ( HOMA ‐ IR ) and β‐cell function ( HOMA ‐B). The development of periodontal disease was measured by means of the incidence of deepened periodontal pockets (4 mm deep or deeper) during the follow‐up period. Incidence rate ratios ( IRR ) were estimated using Poisson regression models. Results Both HOMA ‐ IR and HOMA ‐B indices were associated with periodontal pocket formation during the 4‐year follow‐up. Conclusion The results of this follow‐up study suggest that impaired glucose metabolism measured as insulin resistance and altered beta cell function predict the breakdown of periodontal tissues. Further studies about their role in the pathogenesis of periodontal diseases are needed.