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Serum osteoprotegerin and periodontal destruction in subjects with type 1 diabetes mellitus
Author(s) -
Antonoglou Georgios,
Knuuttila Matti,
Nieminen Pentti,
Vainio Olli,
Hiltunen Liisa,
Raunio Taina,
Niemelä Onni,
Hedberg Pirjo,
Karttunen Riitta,
Tervonen Tellervo
Publication year - 2013
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12129
Subject(s) - osteoprotegerin , medicine , diabetes mellitus , type 2 diabetes mellitus , periodontitis , periodontal disease , dentistry , endocrinology , receptor , activator (genetics)
Aim Besides their role in bone metabolism, receptor activator of nuclear factor‐kappaB ligand ( RANKL ) and osteoprotegerin ( OPG ) are also known to be associated with inflammation. We explored associations between the extent/severity of periodontitis and circulating levels of sRANKL and OPG and their ratio using a cross‐sectional study design. Subjects & methods The extent of periodontal inflammation and tissue destruction and the serum levels of sRANKL (pg/ml) and OPG (pg/ml) were determined in 80 subjects with type 1 diabetes mellitus ( T1DM ). Plaque‐, age‐, gender‐, smoking‐, HbA1c‐ and body mass index‐adjusted associations between periodontal parameters and serum sRANKL , OPG and their ratio were studied using multiple linear regression analysis. Results Adjusted regression analyses of all the subjects indicated a significant positive association between AL ≥ 4 mm and severity of periodontitis and the level of serum OPG . A major drop in the strength and statistical significance of the above association was observed when the analyses included only non‐smokers. Serum sRANKL level and sRANKL / OPG ratio were not associated with periodontitis. Conclusion Our observations suggest that serum OPG may be an indicator of periodontal tissue destruction in T1DM .