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MMP‐9 ‐1562C>T contributes to periodontitis susceptibility
Author(s) -
Pan Yongchu,
Li Dandan,
Cai Qi,
Zhang Weibing,
Ma Junqing,
Wang Meilin,
Wang Lin
Publication year - 2013
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12035
Subject(s) - periodontitis , odds ratio , meta analysis , medicine , matrix metalloproteinase , gastroenterology
Aim The study was conducted to explore the potential association of Matrix metalloproteinases ( MMP ) ‐9 ‐1562C>T with susceptibility to periodontitis. Materials and Methods Electronic literature searches of PubMed, EMBASE and EBSCO databases were performed. Fixed‐effects or random‐effects models were used to calculate the pooled odds ratios (ORs) for four genetic comparisons. Results Seven eligible studies with a total of 628 cases and 689 controls were recruited in the pooled analysis. We found MMP‐9 ‐1562C>T contributed to decreased risk of chronic periodontitis. Furthermore, the polymorphism was associated with modified risk of periodontitis among Caucasian populations. Conclusions This study indicated that MP‐9 ‐1562C>T might be involved in the development of periodontitis. A replication of our results in independent large analysis populations is necessary to give evidence to our observation.