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Gingival crevicular fluid levels of matrix metalloproteinases cross‐sectionally related to periodontitis and metabolic syndrome in community Koreans
Author(s) -
Han DongHun,
Shin HyeSun,
Paek Domyung,
Kim HyunDuck
Publication year - 2012
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12014
Subject(s) - periodontitis , confounding , medicine , matrix metalloproteinase , metabolic syndrome , dentistry , obesity
Background Metabolic syndrome (MetS) may be associated with periodontitis. This study aimed to investigate whether the existence of periodontitis and MetS is cross‐sectionally associated with matrix metalloproteinase ( MMP ) in gingival crevicular fluid ( GCF ) among community Koreans. Materials and Methods Medical and periodontal parameters were evaluated by physicians and dentists in 314 subjects (199 healthy, 58 only periodontitis, 34 only MetS and 23 both). The community periodontal index was used to assess periodontitis. MMP ‐8, 9, 13 were determined by enzyme‐linked immunosorbent assay. Age, gender, monthly household income, smoking and drinking were interviewed as confounders. Analysis of covariance ( ANCOVA ) was applied. Gender‐stratified analyses were applied. Results After controlling for various confounders, MMP ‐8, MMP ‐9 and MMP ‐13 in GCF were significantly associated with periodontitis in both genders and MMP ‐9, MMP ‐13 were associated with MetS in women. MMP ‐8, MMP ‐9 and MMP ‐13 showed association with periodontitis–MetS coexistence non‐synergistically in both genders. MMP ‐9 was synergistically associated with periodontitis–MetS coexistence in women. Conclusion Our results suggest that MMP ‐8, MMP ‐9, MMP ‐13 in GCF were independently related to coexistence of periodontitis and MetS. MMP ‐9 and MMP ‐13 could be an appropriate common indicator of periodontitis and MetS in women. Further studies might guarantee that MMP s in GCF could screen periodontitis and MetS.