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In‐office treatment for dentin hypersensitivity: a systematic review and network meta‐analysis
Author(s) -
Lin PoYen,
Cheng YaWen,
Chu ChiaYi,
Chien KuoLiong,
Lin ChunPin,
Tu YuKang
Publication year - 2013
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12011
Subject(s) - placebo , medicine , meta analysis , dentin hypersensitivity , confidence interval , strictly standardized mean difference , occlusion , randomized controlled trial , credible interval , dentistry , anesthesia , dentin , pathology , alternative medicine
Aim Dentin hypersensitivity, caused by the exposure and patency of dentinal tubules, can affect patients' quality of life. The aim of this study was to undertake a systematic review and a network meta‐analysis, comparing the effectiveness in resolving dentin hypersensitivity among different in‐office desensitizing treatments. Materials and Methods A literature search was performed with electronic databases and by hand until December 2011. The included trials were divided into six treatment groups as placebo, physical occlusion, chemical occlusion, nerve desensitization, laser therapy and combined treatments. The treatment effects between groups were estimated with standardized mean differences by using a Bayesian network meta‐analysis. Results Forty studies were included. The standardized mean difference between placebo and physical occlusion was −2.57 [95% credible interval ( CI ): −4.24 to −0.94]; placebo versus chemical occlusion was −2.33 (95% CI : −3.65 to −1.04); placebo versus nerve desensitization was −1.72 (95% CI : −4.00 to 0.52); placebo versus laser therapy was −2.81 (95% CI : −4.41 to −1.24); placebo versus combined treatment was −3.47 (95% CI : −5.99 to −0.96). The comparisons of the five active treatments showed no significant differences. Conclusions The results from network meta‐analysis showed that most active treatment options had significantly better treatment outcome than placebo.