Open AccessTranscriptomic profile investigations highlight a putative role for NUDT16 in sepsis
Author(s) -
Huang Susie Shih Yin,
Rinchai Darawan,
Toufiq Mohammed,
Kabeer Basirudeen Syed Ahamed,
Roelands Jessica,
Hendrickx Wouter,
Boughorbel Sabri,
Bedognetti Davide,
Van Panhuys Nicholas,
Chaussabel Damien,
Garand Mathieu
Publication year - 2022
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.17240
Subject(s) - sepsis , transcriptome , innate immune system , biology , immune system , immunology , computational biology , bioinformatics , gene , gene expression , genetics
Sepsis is an aberrant systemic inflammatory response mediated by the acute activation of the innate immune system. Neutrophils are important contributors to the innate immune response that controls the infection, but harbour the risk of collateral tissue damage such as thrombosis and organ dysfunction. A better understanding of the modulations of cellular processes in neutrophils and other blood cells during sepsis is needed and can be initiated via transcriptomic profile investigations. To that point, the growing repertoire of publicly accessible transcriptomic datasets serves as a valuable resource for discovering and/or assessing the robustness of biomarkers. We employed systematic literature mining, reductionist approach to gene expression profile and empirical in vitro work to highlight the role of a Nudix hydrolase family member, NUDT16, in sepsis. The relevance and implication of the expression of NUDT16 under septic conditions and the putative functional roles of this enzyme are discussed.