Open AccessInnate lymphoid cells are double‐edged swords under the mucosal barrier
Author(s) -
Duan Zhen,
Liu Mandie,
Yuan Lin,
Du Xizi,
Wu Mengping,
Yang Yu,
Wang Leyuan,
Zhou Kai,
Yang Ming,
Zou Yizhou,
Xiang Yang,
Qu Xiangping,
Liu Huijun,
Qin Xiaoqun,
Liu Chi
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16856
Subject(s) - innate lymphoid cell , mucus , immunology , inflammation , barrier function , mucous membrane , biology , immunity , lymphatic system , lung , innate immune system , microbiology and biotechnology , medicine , immune system , ecology
As the direct contacting site for pathogens and allergens, the mucosal barrier plays a vital role in the lungs and intestines. Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathophysiological processes, such as maintaining or disrupting barrier integrity, preventing various pathogenic invasions. In the pulmonary mucosae, ILCs sometimes aggravate inflammation and mucus hypersecretion but restore airway epithelial integrity and maintain lung tissue homeostasis at other times. In the intestinal mucosae, ILCs can increase epithelial permeability, leading to severe intestinal inflammation on the one hand, and assist mucosal barrier in resisting bacterial invasion on the other hand. In this review, we will illustrate the positive and negative roles of ILCs in mucosal barrier immunity.