Open AccessDrivers of phenotypic variation in cartilage: Circadian clock genes
Author(s) -
Song Xiaopeng,
Bai Hui,
Meng Xinghua,
Xiao Jianhua,
Gao Li
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16768
Subject(s) - phenotype , osteoarthritis , cartilage , biology , circadian rhythm , gene , circadian clock , endogeny , rheumatoid arthritis , sox9 , microbiology and biotechnology , arthritis , immune system , bioinformatics , immunology , medicine , gene expression , neuroscience , genetics , pathology , endocrinology , anatomy , alternative medicine
Abstract Endogenous homeostasis and peripheral tissue metabolism are disrupted by irregular fluctuations in activation, movement, feeding and temperature, which can accelerate negative biological processes and lead to immune reactions, such as rheumatoid arthritis (RA) and osteoarthritis (OA). This review summarizes abnormal phenotypes in articular joint components such as cartilage, bone and the synovium, attributed to the deletion or overexpression of clock genes in cartilage or chondrocytes. Understanding the functional mechanisms of different genes, the differentiation of mouse phenotypes and the prevention of joint ageing and disease will facilitate future research.