Open AccessPrimary ciliogenesis is a crucial step for multiciliated cell determinism in the respiratory epithelium
Author(s) -
Belgacemi Randa,
Diabasana Zania,
Hoarau Antony,
Dubernard Xavier,
Mérol JeanClaude,
Ruaux Christophe,
Polette Myriam,
Perotin JeanneMarie,
Deslée Gaëtan,
Dormoy Valérian
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16729
Subject(s) - cilium , ciliogenesis , respiratory epithelium , motile cilium , biology , epithelium , respiratory mucosa , context (archaeology) , mucociliary clearance , cystic fibrosis , microbiology and biotechnology , respiratory system , primary ciliary dyskinesia , pathology , lung , medicine , anatomy , genetics , bronchiectasis , paleontology
The alteration of the mucociliary clearance is a major hallmark of respiratory diseases related to structural and functional cilia abnormalities such as chronic obstructive pulmonary diseases (COPD), asthma and cystic fibrosis. Primary cilia and motile cilia are the two principal organelles involved in the control of cell fate in the airways. We tested the effect of primary cilia removal in the establishment of a fully differentiated respiratory epithelium. Epithelial barrier integrity was not altered while multiciliated cells were decreased and mucous‐secreting cells were increased. Primary cilia homeostasis is therefore paramount for airway epithelial cell differentiation. Primary cilia‐associated pathophysiologic implications require further investigations in the context of respiratory diseases.