Open AccessMicroRNA‐206 has a bright application prospect in the diagnosis of cases with oral cancer
Author(s) -
Wang Lili,
Song Hongguang,
Yang Shiming
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16598
Subject(s) - receiver operating characteristic , medicine , cancer , stage (stratigraphy) , area under the curve , oncology , microrna , lymph node metastasis , real time polymerase chain reaction , gastroenterology , metastasis , pathology , biology , biochemistry , gene , paleontology
Previous studies have shown that microRNA‐206 ( miR‐206 ) exhibits anti‐tumour properties in various tumours. Nevertheless, diagnostic significance of miR‐206 in oral cancer is still poorly known. Our research was carried out to explore the performance of miR‐206 in the diagnosis of oral cancer. Quantitative real‐time polymerase chain reaction (qRT‐PCR) method was adopted to measure the level of miR‐206 in serum specimens from oral cancer cases and control individuals. Chi‐square test was performed to analyse the correlation between miR‐206 level and clinicopathological parameters of the cases. Receiver operating characteristic (ROC) curve was constituted to assess diagnostic accuracy of miR‐206 in oral cancer. Serum miR‐206 level in oral cancer patients was significantly lower than that in control individuals ( P < .001). miR‐206 expression was obviously related to T classification ( P = .033), TNM stage ( P = .008) and lymph node metastasis ( P = .028). The area under the curve (AUC) of the ROC curve was 0.846 (95% CI = 0.797‐0.896, P < .001) with a specificity of 72.7% and a sensitivity of 81.2%. It revealed that miR‐206 might be a non‐invasive indicator in differentiating oral cancer cases from control individuals. Down‐regulation of miR‐206 is related to the development of oral cancer. Serum miR‐206 might be an effective indicator for early detection of oral cancer.