Open AccessCircular RNA in colorectal cancer
Author(s) -
Li Toni,
Wang Wei Cen,
McAlister Vivian,
Zhou Qinfeng,
Zheng Xiufen
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16380
Subject(s) - colorectal cancer , circular rna , metastasis , bioinformatics , cancer , long non coding rna , rna , medicine , biology , cancer research , oncology , gene , genetics
Circular RNA (circRNA) is a highly abundant type of single‐stranded non‐coding RNA. Novel research has discovered many roles of circRNA in colorectal cancer (CRC) including proliferation, metastasis and apoptosis. Furthermore, circRNAs also play a role in the development of drug resistance and have unique associations with tumour size, staging and overall survival in CRC that lend circRNAs the potential to serve as diagnostic and prognostic biomarkers. Among cancers worldwide, CRC ranks second in mortality and third in incidence. In order to have a better understanding of the influence of circRNA on CRC development and progression, this review summarizes the role of specific circRNAs in CRC and evaluates their potential value as therapeutic targets and biomarkers for CRC. We aim to provide insight in the development of therapy and clinical decision‐making.