Open AccessSerum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
Author(s) -
Xu Chunhua,
Li Li,
Wang Wei,
Zhang Qian,
Zhang Xiuwei,
Yang Rusong
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16360
Subject(s) - macrophage migration inhibitory factor , lung cancer , medicine , biomarker , cytokine , oncology , immunology , univariate analysis , lung , multivariate analysis , biology , biochemistry
The aim of this study was to investigate the value of serum macrophage inhibitory factor‐1 (MIC‐1) level in patients with non–small cell lung cancer (NSCLC). Serum samples from 296 patients with NSCLC and 240 healthy controls were collected. The levels of serum MIC‐1 were determined by ELISA. The serum MIC‐1 levels in NSCLC patients were higher than that of the controls ( P <.001). Univariate and multivariate Cox regression analysis showed that serum MIC‐1 was an independent prognostic indicator of OS and PFS. Serum MIC‐1 is a valuable biomarker for the diagnosis and prognosis of NSCLC.