Open AccessRole of melatonin in the dynamics of acute spinal cord injury in rats
Author(s) -
Bi Jiaqi,
Shen Jianxiong,
Chen Chong,
Li Zheng,
Tan Haining,
Sun Peiyu,
Lin Youxi
Publication year - 2021
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16325
Subject(s) - melatonin , spinal cord , spinal cord injury , medicine , apoptosis , anesthesia , inflammation , central nervous system , pharmacology , biology , biochemistry , psychiatry
Abstract Melatonin is well‐documented to have the ability of reducing nerve inflammation and scavenging free radicals. However, the therapeutic effect of melatonin on spinal cord injury has not been fully described. In this study, we assessed the effect of melatonin on T9 spinal cord injury established by Allen method in rats. Melatonin deficiency significantly delayed the recovery of sensory and motor functions in SCI rats. Treatment with melatonin significantly alleviated neuronal apoptosis and accelerated the recovery of spinal cord function. These results suggest that melatonin is effective to ameliorate spinal cord injury through inhibition of neuronal apoptosis and promotion of neuronal repair.