Open AccessAcetate: Friend or foe against breast tumour growth in the context of obesity?
Author(s) -
Yelek Caner,
Mignion Lionel,
Joudiou Nicolas,
Terrasi Romano,
Gourgue Florian,
Van Hul Matthias,
Delzenne Nathalie,
Gallez Bernard,
Corbet Cyril,
Muccioli Giulio G.,
Feron Olivier,
Cani Patrice D.,
Jordan Bénédicte F.
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.16034
Subject(s) - adipose tissue , endocrinology , breast cancer , medicine , context (archaeology) , obesity , lipid metabolism , cancer , weight gain , chemistry , biology , cancer research , body weight , paleontology
Acetate is reported as a regulator of fat mass but also as lipogenic source for cancer cells. Breast cancer is surrounded by adipose tissue and has been associated with obesity. However, whether acetate contributes to cancer cell metabolism as lipogenic substrate and/or by changing fat storage and eventually obesity‐induced breast cancer progression remains unknown. Therefore, we studied the contribution of acetate to breast cancer metabolism and progression. In vitro, we found that acetate is not a bioenergetic substrate under normoxia and did not result in a significant change of growth. However, by using lipidomic approaches, we discovered that acetate changes the lipid profiles of the cells under hypoxia. Moreover, while mice fed a high‐fat diet (HFD) developed bigger tumours than their lean counterparts, exogenous acetate supplementation leads to a complete abolishment of fat mass gain without reverting the HFD‐induced obesity‐driven tumour progression. In conclusion, although acetate protects against diet‐induced obesity, our data suggest that it is not affecting HFD‐driven tumour progression.