Open AccessDown‐regulation of diesel particulate matter‐induced airway inflammation by the PDZ motif peptide of ZO‐1
Author(s) -
Kang Dong Hee,
Lee TaeJin,
Kim Ji Wook,
Shin Yu Som,
Kim Ju Deok,
Ryu Sung Won,
Ryu Siejeong,
Choi Yung Hyun,
Kim Cheol Hong,
You EunAe,
Rhee SangMyung,
Song Kyoung Seob
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15843
Subject(s) - pdz domain , inflammation , bronchoalveolar lavage , peptide , microbiology and biotechnology , cytokine , chemistry , immunology , biology , cancer research , medicine , biochemistry , lung
Although diesel airborne particulate matter (PM2.5) has been known to play a role in many human diseases, there is no direct evidence that therapeutic drugs or proteins can diminish PM2.5‐induced diseases. Nevertheless, studies examining the negative control mechanisms of PM2.5‐induced diseases are critical to develop novel therapeutic medications. In this study, the consensus PDZ peptide of ZO‐1 inhibited PM2.5‐induced inflammatory cell infiltration, pro‐inflammatory cytokine gene expression, and TEER in bronchoalveolar lavage (BAL) fluid and AM cells. Our data indicated that the PDZ domain in ZO‐1 is critical for regulation of the PM2.5‐induced inflammatory microenvironment. Therefore, the PDZ peptide may be a potential therapeutic candidate during PM‐induced respiratory diseases.