Open AccessCircPSMC3 alleviates the symptoms of PCOS by sponging miR‐296‐3p and regulating PTEN expression
Author(s) -
Liu Jun,
Ding Jinli,
Qu Bing,
Liu Jiuying,
Song Xiaojie,
Suo Qingli,
Zhou Aifen,
Yang Jing
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15747
Subject(s) - pten , polycystic ovary , apoptosis , endocrine system , cancer research , pathogenesis , anovulation , infertility , biology , cell cycle , cell growth , etiology , cell , medicine , bioinformatics , endocrinology , insulin resistance , insulin , pi3k/akt/mtor pathway , hormone , pregnancy , genetics
Polycystic ovary syndrome (PCOS), the most common female endocrine disease that causes anovulatory infertility, still lacks promising strategy for the accurate diagnosis and effective therapeutics of PCOS attributed to its unclear aetiology. In this study, we determined the abnormal reduction in circPSMC3 expression by comparing the ovarian tissue samples of PCOS patients and normal individuals. The symptom relief caused by up‐regulation of circPSMC3 in PCOS model mice suggested the potential for further study. In vitro functional experiments confirmed that circPSMC3 can inhibit cell proliferation and promote apoptosis by blocking the cell cycle in human‐like granular tumour cell lines. Mechanism study revealed that circPSMC3 may play its role through sponging miR‐296‐3p to regulate PTEN expression. Collectively, we preliminarily characterized the role and possible insights of circPSMC3/miR‐296‐3p/PTEN axis in the proliferation and apoptosis of KGN cells. We hope that this work provides some original and valuable information for the research of circRNAs in PCOS, not only to better understand the pathogenesis but also to help provide new clues for seeking for the future therapeutic target of PCOS.