Open AccessLINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β‐catenin signaling pathway
Author(s) -
Ai Yilong,
Wu Siyuan,
Zou Chen,
Wei Haigang
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15667
Subject(s) - wnt signaling pathway , cancer research , biology , catenin , cell growth , signal transduction , beta catenin , transcription factor , cell , microbiology and biotechnology , gene , genetics
Dysregulation of long non‐coding RNAs (lncRNAs) has been implicated in many cancer developments. Previous studies showed that lncRNA LINC00941 was aberrantly expressed in oral squamous cell carcinoma (OSCC). However, its role in OSCC development remains elusive. In this study, we demonstrated that in OSCC cells, EP300 activates LINC00941 transcription through up‐regulating its promoter H3K27ac modification. Up‐regulated LINC00941 in turn activates CAPRIN2 expression by looping to CAPRIN2 promoter. Functional assays suggest that both LINC00941 and CAPRIN2 play pivotal roles in promoting OSCC cell proliferation and colony formation. In vivo assay further confirmed the role of LINC00941 in promoting OSCC cell tumour formation. Lastly, we showed that the role of LINC00941 and CAPRIN2 in OSCC progression was mediated through activating the canonical WNT/β‐catenin signaling pathway. Thus, LINC00941/CAPRIN2/ WNT/β‐catenin signaling pathway provides new therapeutic targets for OSCC treatment.