Open AccessPhysiological and pathophysiological role of ion channels and transporters in the colorectum and colorectal cancer
Author(s) -
Zhang Minglin,
Li Taolang,
Zhu Jiaxing,
Tuo Biguang,
Liu Xuemei
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15600
Subject(s) - colorectal cancer , transporter , mouse model of colorectal and intestinal cancer , cancer , ion channel , homeostasis , medicine , solute carrier family , cancer research , bioinformatics , chemistry , biology , biochemistry , receptor , gene
The incidence of colorectal cancer has increased annually, and the pathogenesis of this disease requires further investigation. In normal colorectal tissues, ion channels and transporters maintain the water‐electrolyte balance and acid/base homeostasis. However, dysfunction of these ion channels and transporters leads to the development and progression of colorectal cancer. Therefore, this review focuses on the progress in understanding the roles of ion channels and transporters in the colorectum and in colorectal cancer, including aquaporins (AQPs), Cl − channels, Cl − / HCO 3 ‐ exchangers, Na + / HCO 3 ‐ transporters and Na + /H + exchangers. The goal of this review is to promote the identification of new targets for the treatment and prognosis of colorectal cancer.