Open AccessThe Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives
Author(s) -
Quoc Lam Bao,
Shrivastava Sushant K.,
Shrivastava Anju,
Shankar Sharmila,
Srivastava Rakesh K.
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15413
Subject(s) - obesity , diabetes mellitus , pancreatic cancer , medicine , cancer , carcinogenesis , type 2 diabetes , endocrinology , alcohol consumption , population , type 2 diabetes mellitus , gerontology , physiology , environmental health , biology , alcohol , biochemistry
The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer‐related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, metabolism and microenvironment within the pancreas can also modulate pancreatic carcinogenesis. The risk of PC on a population level may be reduced by modifiable lifestyle risk factors. In this review, the interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of diabetes and PC were discussed.