Open AccessProgress in the application of organoids to breast cancer research
Author(s) -
Yang Liping,
Liu Baoer,
Chen Haodong,
Gao Rui,
Huang Kanghua,
Guo Qiuyi,
Li Feng,
Chen Weicai,
He Jinsong
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15216
Subject(s) - organoid , breast cancer , drug discovery , human breast , cancer , metastasis , medicine , bioinformatics , biology , neuroscience
Breast cancer is the most common cancer diagnosed in women. Breast cancer research is currently based mainly on animal models and traditional cell culture. However, the inherent species gap between humans and animals, as well as differences in organization between organs and cells, limits research advances. The breast cancer organoid can reproduce many of the key features of human breast cancer, thereby providing a new platform for investigating the mechanisms underlying the development, progression, metastasis and drug resistance of breast cancer. The application of organoid technology can also promote drug discovery and the design of individualized treatment strategies. Here, we discuss the latest advances in the use of organoid technology for breast cancer research.