Open AccessNONO and tumorigenesis: More than splicing
Author(s) -
Feng Peifu,
Li Ling,
Deng Tanggang,
Liu Yan,
Ling Neng,
Qiu Siyuan,
Zhang Lin,
Peng Bo,
Xiong Wei,
Cao Lanqin,
Zhang Lei,
Ye Mao
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15141
Subject(s) - carcinogenesis , alternative splicing , rna splicing , biology , rna binding protein , microbiology and biotechnology , dna damage , gene , dna repair , dna , rna , genetics , messenger rna
The non‐POU domain‐containing octamer‐binding protein NONO/p54 nrb , which belongs to the Drosophila behaviour/human splicing (DBHS) family, is a multifunctional nuclear protein rarely functioning alone. Emerging solid evidences showed that NONO engages in almost every step of gene regulation, including but not limited to mRNA splicing, DNA unwinding, transcriptional regulation, nuclear retention of defective RNA and DNA repair. NONO is involved in many biological processes including cell proliferation, apoptosis, migration and DNA damage repair. Dysregulation of NONO has been found in many types of cancer. In this review, we summarize the current and fast‐growing knowledge about the regulation of NONO, its biological function and implications in tumorigenesis and cancer progression. Overall, significant findings about the roles of NONO have been made, which might make NONO to be a new biomarker or/and a possible therapeutic target for cancers.