Open AccessE‐cadherin deregulation in breast cancer
Author(s) -
Corso Giovanni,
Figueiredo Joana,
De Angelis Simone Pietro,
Corso Federica,
Girardi Antonia,
Pereira Joana,
Seruca Raquel,
Bonanni Bernardo,
Carneiro Patricia,
Pravettoni Gabriella,
Guerini Rocco Elena,
Veronesi Paolo,
Montagna Giacomo,
Sacchini Virgilio,
Gandini Sara
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.15140
Subject(s) - cdh1 , cadherin , breast cancer , cancer research , cancer , gene , biomarker , medicine , biology , oncology , bioinformatics , genetics , cell
Abstract E‐cadherin protein ( CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.