Open AccessThe emerging role of cellular senescence in renal diseases
Author(s) -
Zhou Bingru,
Wan Ying,
Chen Rong,
Zhang Chunmei,
Li Xuesen,
Meng Fanyin,
Glaser Shan,
Wu Nan,
Zhou Tianhao,
Li Siwen,
Francis Heather,
Alpini Gianfranco,
Zou Ping
Publication year - 2020
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/jcmm.14952
Subject(s) - senescence , regeneration (biology) , biology , cellular senescence , phenotype , microbiology and biotechnology , ageing , cell , bioinformatics , cancer research , genetics , gene
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence prevention, but it is also involved in many cardiovascular, renal and liver diseases through the senescence‐associated secretory phenotype (SASP). This review summarizes the molecular mechanisms underlying cellular senescence and its possible effects on a variety of renal diseases. We will also discuss the therapeutic approaches based on the regulation of senescent and SASP blockade, which is considered as a promising strategy for the management of renal diseases.